Professor of Paediatric Tropical Infectious Diseases at the Faculty of Medicine and Director of the ICCARE Centre at the Institute for Global Health Innovation, Imperial College, London and an Honorary Fellow at MRC Clinical Trials Unit, University College, London.

Over the last 20 years I have been based full-time at the East Africa, where I lead a research group that have highlighted the unique importance of emergency-care research, previously poorly appreciated as an area for specific funder or policy investment, as a highly targeted and cost-effective means of tackling childhood mortality in resource-limited sub-Saharan Africa. As a clinical investigator my work has focused upon understanding the pathophysiology and conducting clinical trials of emergency interventions to improve outcome. To enable such translational research to occur, I have built up a network of African sites and collaborations spanning the globe bringing sophisticated technologies to apply them in real life circumstances to study common diseases of Africa. These have enabled unique insights in host clinical physiology, which have major impacts on disease management and clinical trials that have generated the essential evidence base for patient management and contributed to the development of national and international guidelines.