Manu Shankar-Hari is a clinician-scientist in Intensive Care Medicine and leads a translational research group at King’s College London. Manu obtained his PhD from King’s College London, for his work on B cell abnormalities in sepsis and completed his formal training in epidemiology from the London School of Hygiene and Tropical Medicine. He holds the prestigious National Institute for Health Research (NIHR) Clinician Scientist Award in Intensive Care Medicine.

Shankar-Hari group’s research explores ways to improve outcomes in adult critically ill patients with sepsis and with ARDS, by linking the illness immunobiology with novel interventional trial designs.

Our lab has the following focussed research themes

  1. Immunobiology: Explore adaptive immune system changes during sepsis, during ARDS and longer-term in patients who survive sepsis. We integrate orthogonal multilevel data with repeated measurements of cellular phenotype, functional assessments, alongside corresponding transcriptomes and epigenetic landscapes.
  2. Epidemiology and Stratified medicine: We use early-phase randomised controlled trials, cohort studies, systematic reviews and large clinical trial datasets to (a) explore treatment effect heterogeneity; (b) identify treatable traits based on dominant biological mechanisms, and (c) modifiable proximate determinants of sepsis and ARDS.

For further details, please see webpage: https://www.kcl.ac.uk/research/shankar-hari-group