Paul originally studied undergraduate physics and then medicine. Graduating from The Manchester Medical School 1989, he went on to study clinical academic surgery, emergency medicine and critical care at the Universities of Glasgow and Manchester in the UK, and at the Catholic University of Leuven, Belgium.

He returned to Manchester in 1998 as MRC Clinical Training Fellow, completing his PhD supervised by Professor Rod Little at the MRC Trauma Unit in 2002, where he developed non-invasive methods to transduce and study dynamic cardio-respiratory responses to tissue injury and haemorrhage.

He was appointed to his current substantive clinical academic post at the University of Manchester in 2003, developing clinical services and academic practice in Critical Care Medicine as Honorary NHS Consultant at Salford Royal NHS Foundation Trust. He developed and provides leadership for a programme of work, funded largely by the National Institute of Health Research (NIHR), investigating and assessing the diagnostic utility of emerging molecular technologies in the setting of sterile tissue injury and severe infection. Funded by Innovate UK (formerly Technology Strategy Board) he has also led a programme of work developing novel technologies aimed at rapid point-of-care infection/sepsis diagnosis.

He is NIHR’s National Specialty Lead for Critical Care providing leadership oversight for a range of large-scale pragmatic clinical trials in the UK and he represents NIHR internationally. He served on NIHR’s Urgent Public Health Research Advisory Group, providing expert advice on research priroity for DHSC and UK’s CMOs during the COVID-19 pandemic. From April 2021, succeeding Professor Steve Smye, Paul was appointed as NIHR National Specialty Cluster Lead at King’s College London, providing strategic oversight and guidance for research in Trauma and Emergency Care, Anaesthesia, Peri-operative medicine, Pain medicine, Critical Care, Dermatology and Imaging Science. In addtion, he is Research Professor in The Humanitarian and Conflict Response Institute at The University of Manchester, providing strategic interdisciplinary collaborative leadership and translation of acute care research in low resource settings.